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084f2db8c6 to 06:00 a.m.) and lower risk during the night time period (21:00 p.m. College of Pharmacy, Department of Pharmaceutics, King Saud University, Riyadh, Saudi Arabia. Through the preliminary experiments, we selected the melting method other than co-evaporation method, because the melting procedure seemed to be more convenient and it involved with no organic solvent during preparation process, which ensured a cost-effective method of production.All the excipients and drug were firstly screened through 100-mesh sieve and mixed uniformly to obtain the physical mixture, then melted the physical mixture with stir, followed by cooling and pulverization of the obtained product. Abstract. Keywords: Solubility Enhancement, Solid Dispersion, Methods for Solubility Enhancement, Bioavailability Enhancement.. Screen reader users, click the load entire article button to bypass dynamically loaded article content. Cookies are required to use this site.